Biologics

A hydrogel that adheres firmly to cartilage and meniscus

November 21, 2018, Ecole Polytechnique Federale de Lausanne

EPFL researchers have developed a hydrogel – made up of nearly 90% water – that naturally adheres to soft tissue like cartilage and the meniscus. If the hydrogel carries repair cells, it could help damaged tissue to heal.

Some types of body tissue, like cartilage and meniscus, have little or no blood supply and are unable to heal if damaged. One promising approach to this problem is to inject a hydrogel loaded with repair cells or drugs into the damaged area in the hope of stimulating tissue regeneration.

However, commercial  do not stay put after being applied to the treatment area because of pressure from the body’s movements and the flow of bodily fluids. Doctors therefore use special membranes to keep the hydrogel in place, yet those membranes are attached with sutures that perforate the very tissue the hydrogel is supposed to heal.

Two EPFL  groups, led by Dominique Pioletti and Pierre-Etienne Bourban, have created a biocompatible hydrogel that naturally adheres to  like cartilage and the meniscus. Their hydrogel, which is almost 90% water, can withstand  and extensive deformation and therefore eliminates the need for a separate binding process. Their research has been published in ACS Applied Materials & Interfaces.

“Our hydrogel is ten times more adhesive than currently available bioadhesives on the market such as fibrin,” says Pioletti, head of the Laboratory of Biomechanical Orthopedics in EPFL’s School of Engineering. “And thanks to its high water content, our hydrogel is very similar in nature to the natural tissue it’s designed to heal.”

READ THE REST HERE 

 

Photo Credit: Ecole Polytechnique Federale de Lausanne

Tags

Mason Krell

Mason began his career in the Orthopedic Industry in 2017 when he joined The De Angelis Group as a Research Manager. He has developed a strong network within the industry and is very dedicated to helping companies maximize opportunities and disrupt markets.

Related Articles

Leave a Reply

Your email address will not be published. Required fields are marked *

Close
Themed By Curio Display Cabinets