AOI Medical, Inc. Announces Research Update

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London, UK, 31 March 2009 – AOI Medical, Inc. (the “Company” or “AOI”)(AIM: AOI), a medical device company focusing on innovative orthopaedicmedical devices for the spine and trauma markets, has successfullycompleted surgical procedures on thirty (30) patientsin a clinical trial with AscendxTM Vertebral Compression Fracture(“VCF”) Reduction System (“AscendxTM”) at six sites across the UnitedStates. The board is pleased with the progress of the clinical trialand results to date; evaluation of clinical outcomes is ongoing.

William J. Christy, CEO of AOI Medical, said: “The clinical program hasgained momentum and we are pleased with our progress to date. TheAscendxTM system is designed to provide notable improvements in the wayphysicians traditionally treat VCFs. While all currently existing VCFprocedures offer immediate pain relief to the patient, the AscendxTMtechnology is specifically designed to provide a mechanical, repeatablecutting of cancellous bone and to deliver an even distribution of thebone cement.” Over time, these features may potentially providebenefits with respect to clinical outcomes, subject to ongoing clinicalevaluation.

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