Is Use of Bone-Morphogenetic Proteins for Spine Fusion Surgery Cost-effective?

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Prevalence, Complications, and Hospital Charges Associated With Use of Bone-Morphogenetic Proteins in Spinal Fusion Procedures

Kevin S. Cahill, MD, PhD, MPH; John H. Chi, MD, MPH; Arthur Day, MD; Elizabeth B. Claus, MD, PhD

Context: No national data exist to examine use of bone-morphogenetic proteins (BMPs) in spinal fusion surgery.

Objective: To determine the patterns of use and rates of complications and financial charges associated with BMP use in spinal fusion nationally.

Design, Setting, and Patients: Retrospective cohort study of 328 468 patients undergoing spinal fusion procedures from 2002-2006 identified from the Nationwide Inpatient Sample database, a 20% sample of US community hospitals.

Main Outcome Measures: The rates of use of BMP among patients undergoing spinal fusion procedures are examined along with complications, length of stay, and hospital charges associated with use of this fusion adjunct.

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